1.Serotonin transporter (SERT) and norepinephrine transporter (NET) locate in the nerve presynaptic membrane. They are responsible for terminating the action of 5-HT and NE in the synapse.
5-羟色胺转运体(serotonin transporter，SERT)和去甲肾上腺素转运体(norepinephrine transporter，NET)位于神经突触前膜，分别负责回吸收突触间隙的5-HT、NE，因此它们在调节细胞外神经递质的浓度方面起重要作用。
2.ForewordThe transporter associated with antigen processing (TAP) is a transport protein on endoplasmic reticulum. It plays a pivotal role in the presentation of intracellular antigen by translocating intracellular antigenic peptides from the cy-tosol into the lumen of endoplasmic reticulum (ER). TAP is made up of the TAP1 and TAP2 polypeptides.
前言抗原处理相关转运蛋白(transporter associated with antigen processing protein,TAP)是一种位于内质网膜上的转运蛋白。
3.Study BackgroundBeing a integration membrane protein, ATP-binding cassette transporter A1 (ABCA1) is considered to play an important role in the process of reverse cholesterol transport (RCT) and the primary formation of high density lipoprotein (HDL) by using ATP as a source of energy. So ABCA1 is considered as the keeper of RCT. Mutations of ABCA1 gene may result in Tangier disease and familialhypoalphalipoproteinemia (FHA) .
三磷酸腺苷结合盒转运体A1(ATP-binding cassette transporter A1，ABCA1)是一种整合膜蛋白，它以ATP为能源，在胆固醇逆转运(reverse cholesteroltransport，RCT)和高密度脂蛋白(high density lipoprotein，HDL)生成起始步骤中起重要作用，被称作RCT守门人。
4.In this process, the ATP-binding cassette transporter 1 (ABCA1) protein controls the efflux of intracellular cholesterol to apolipoprotein (apo) AI, the major apolipoprotein of HDL and is crucial for the initial steps.
ATP结合盒转运子Al(ATP-binding cassette transporter Al, ABCAl)控制细胞内胆固醇流出至apoAⅠ(HDL的丰要载脂蛋白)，在RCT过程中起第一步限速作用。
5.However, the remaining three (CDD-193, CDD-218, CDD-470) showed significant homologies with sequences encoding components of an ABC-type transporter, GTPase and 40S ribosomal S3 proteins (RPS3), respectively.
在GenBank中进行同源性比较发现前4个没有同源序列与之匹配; 后3个片段推导的氨基酸序列分别与ABC型transporter,GTPase和40S核糖体蛋白质S3(RPS3)有高度同源性。
6.Theother is amino acid transporter (aat) gene, which neighbor to xooR, is a ATP-bindingprotein and the full-length spans 1377 bp.
相邻的 amino acid transporter(aat)基因是一个跨膜蛋白,全长 1377bp。 Southern 分析表明,这两个基因单拷贝存在基因组中。
7.The transporter associated with antigen processing(TAP) plays a pivotal role in the presentation of intracellular antigen by translocating intracellular antigenic peptides from the cytosol into the lumen of endoplasmic reticulum(ER).
抗原处理相关转运体蛋白(transporter associated with antigen processing,TAP)在内源性抗原提呈过程中有重要作用,负责内源性抗原从胞浆到内质网(ER)腔的转运。
8.AIM:To investigate the effects of tumor necrosis factor-α(TNFα)and pioglitazone on glucose transporter 4(GLUT4)mRNA and protein expression in 3T3-L1 adipocytes,and explore the time dependence.
目的:观察肿瘤坏死因子α和噻唑烷二酮类药物吡格列酮对3T3-L1脂肪细胞中葡萄糖转运子4(glucose transporter4,GLUT4)mRNA和蛋白表达的影响,并了解其是否有时间依赖性。
9.OBJECTIVE: To investigated the effects of high glucose, insulin on expression of Glucose Transporter 4 (GLUT4), Cbl-associated protein (CAP) and cytoskeleton protein F-actin of glomerular mesangial cells (GMCs) in order to explore the function of Glucose Transporter 4, Cb1-associated protein and F-actin in the genesis and development of diabetic nephropathy (DN).
目的：探讨高糖、胰岛素对肾小球系膜细胞GLUT4和CAP的mRNA表达及细胞骨架蛋白F-actin的影响，进一步研究糖尿病肾病发生发展中GLUT4及其下游分子F-actin和CAP的重要作用。
