1.Our previous research showed that severe thoracic trauma could increase LPS, Toll-like receptor 4 (TLR4), a member of the Toll family was found recently, and it is considered to be an important factor in the pathway for the signal transduction of LPS in cells;
前期研究表明，严重胸部创伤能引起机体内毒素(LPS)升高。 新近发现的FLR4(Toll-like receptor 4)是Toll家族成员之一，被认为是LPS胞内信号转导的重要通路。
2.Toll-like receptors,a kind of trans-membrane receptors and pathogen pattern recognition receptors, play important roles in regulating cytophagy, signal transduction and apoptosis during an acute inflammation.
Toll样受体 (Toll likereceptors,TLRs)是新近发现的先天性免疫系统中的细胞跨膜受体及病原模式识别受体之一 ,在急性炎症反应细胞吞噬作用的调节和细胞信号转导及细胞凋亡中起重要作用 .
3.Toll like receptors (TLR) are innate immune molecule in mammal. As pattern recognition receptor (PRR), they play an important role in recognizing and defencing varities of pathogen. TLR1—TLR13 are typical I-type transmembrane receptors which have been founded in mammal since 1997. Among them there are ten types of TLR existing in human (hTLR1—hTLR10) .
Toll样受体(Toll like receptors TLRs)是哺乳动物具备的天然免疫分子,属于模式识别受体(pattern recognition receptor PRR),在识别和抵御各种病原微生物感染中发挥着着重要作用。
4.Pattern recognition receptors (PRR) have been considered to be the important initial steps for cellular recognition of LPS and consequent initiation of LPS responses. Scavenger receptor, CD14, toll-like receptors, β2-integrins and L-selectin have been shown to be involved in the clearance of LPS or LPS activation.
宿主细胞膜上的模式识别受体( patternrecognitionreceptors,PRR)是介导细胞识别LPS,并启动LPS反应的首要环节 ,现已发现清道夫受体 (scavengerreceptor,SR)、CD14、Toll样受体 4(Toll likereceptor 4,TLR4)、TLR2、β2整合素和L selectin等多种膜蛋白参与清除LPS或激活细胞的作用。
5.Toll-like receptor 2 (TLR2) plays a critical role in immune response to mycobacteria. In order to know the TLR2 Arg753Gln single nucleotide polymorphism (SNP) and the relationship with the developing of tuberculosis in Zhejiang Han population, we collected the blood samples from 170 TB patients compared with 199 ethnically and age-matched healthy blood donors.
应用聚合酶链反应-序列特异性引物方法(polymerase chain reaction with sequence specific primer,PCR-SSP),研究浙江地区汉族人群中Toll样受体2(Toll-like receptor2,TLR2)Arg753Gln(G2408A)单核苷酸多态性(single nucleotide polymorphism,SNP)分布及其与肺结核病的易感性的关系。
6.As a member of TLRs (Toll-like receptors) family, TLR9 belongs to pattern recognition receptors and could mediate CpG to stimulate immunocyte. Thus, TLR9 plays an important role in innate immunity and in the connection between acquired immunity and innate immunity .
Toll样受体-9(Toll-like receptor 9,TLR9)是哺乳动物TLRs家族中一员,作为细胞表面的天然模式识别受体,主要参与免疫刺激序列(CpG序列)激活免疫细胞的信号传导,从而在天然抗感染免疫及联系天然免疫和获得性免疫中发挥重要作用。
7.Objective: To study the effects of thymosin α1 on the expression of Toll-like receptor 2(TLR2), myeloid differentiation factor 88(MyD88) and TNF-α in human THP-1 cell line stimulated by bacterial lipoprotein(BLP) with different ways.
目的:观察人THP-1细胞与胸腺肽α1(Tα1)孵育后,予细菌脂蛋白(BLP)刺激后,Toll样受体2(TLR2)、髓系分化因子88(MyD88)蛋白的表达及细胞因子TNF-α的变化。 方法:实验采用人THP-1细胞系进行细胞培养,分为4组:对照组为THP-1细胞不加任何刺激;
8.As TLR (Toll-like receptor) 4 is the major signaling receptor for LPS, many investigations have focused on changes in the TLR4 signaling pathways as a mechanism of endotoxin tolerance.
自从证实TLR (Toll-like receptor) 4是LPS的信号受体以来,内毒素耐受的研究主要集中于信号受体和TLR4胞内信号分子的变化。
9.Expression of Human Toll-like Receptor and β-defensin mRNA in Nasal Mucosa
Toll样受体和β-防御素mRNA在鼻粘膜中的表达
10.Toll-like receptor 9 recognizes CpG motifs in microbial DNA. Then through the signal transfer,B lymphocytes and dendritic cells are activated, meanwhile different kinds of cytokines appear. At last, autoantibodies are produced and the immune network turns to be unbalanced.
其中Toll样受体9识别细菌和病毒DNA中的CpG基序,然后通过信号转导激活B细胞、树突状细胞以及产生各种细胞因子最终导致自身抗体的产生和免疫网络的失衡。
