1.METHODS: A total of 171 IM mucosa (54,76,and 41 cases for type Ⅰ,Ⅱ,and Ⅲ,respectively) and 89 controls (40 and 49 cases for superficial gastritis and gastric cancer,respectively) were included in this study. SP immunohistochemisty was used to detect the expression of HSP60 and H pylori infection was judged by enzyme-linked immunosorbnent assay (ELISA),anti-H pylori IgG detection and H pylori -DNA polymerase chain reaction (PCR),respectively.
方法:对171例肠化胃黏膜组织其中Ⅰ型肠化54例、Ⅱ型肠化76例、Ⅲ型肠化41例,对照组浅表性胃炎40例,胃癌49例,采用SP免疫组织化学技术进行胃黏膜HSP60的检测,用ELISA,H pylori IgG抗体检测及H pylori-DNA PCR方法进行H pylori感染情况的判定.
2.The relationship between H.pylori and the disease of gastroenterology have received considerable attention since H.pylori was separated from the gastric biopsy samples in the gastritis patients by Warren and Marshall in 1983. It is confirmed that H.pylori is highly relevant to chronic gastritis, peptic ulcer, gastric carcinoma, gastric MALT lymphoma and other disease.
自从1983年Warren和Marshall从胃炎患者的胃粘膜中首次分离出幽门螺杆菌(H.pylori)以来,国内外学者对H. pylori与胃肠道疾病的关系进行了大量深入的研究。
3.Background and objective: A close association between Helicobacter pylori(H.pylori) infection and gastric cancer has been affirmed. In 1994, the World Health Organization International Agency for Research on Cancer recognized H.pylori as a definite carcinogen for gastric cancer. However, the definite pathogenesis of H.pylori infection is as yet unclear.
背景及目的：幽门螺杆菌（Helicobacter pylori, Hp）感染与胃癌的发生密切相关已得到公认，1994年世界卫生组织国际癌症研究机构将Hp列为人类Ⅰ类致癌因子，但其确切致癌机制尚不清楚。
4.ObjectiveTo determine the effect of CagA+ Helicobacter pylori(H.pylori)strain and anti-H. pylori drugs on the expression of connexin 43(Cx43) and cell proliferation of BGC-823 cells in vitro,and to investigate the relation between the changes of Cx43 expression, cell proliferation of BGC-823 cells and CagA+H.
目的:观察体外实验中幽门螺杆菌(Helicobacter pylori,H.pylori)CagA+菌株对BGC-823细胞系Cx43表达和细胞增殖的影响,以及抗H.
5.4 weeks after the last immunization, all the mice were challenged with H. pylori Sydney Strain 1 (1×107 CFU to each mouse) and sacrificed 4 weeks after the challenge. Their stomachs were collected for rapid urease test, histologic examination and quantitative culture to observe the gastric H. pylori densities.
免疫完成后4周以H． pylori Sydney Strain1菌株攻击小鼠1次（1×107 CFU／只），攻击后4周处死小鼠，取胃分别作快速尿素酶试验、病理检查及定量细菌培养，观察H．Pylori定植情况。
6.Plasma VIP in patients with DGR was markedly higher than that of non-DGR patients (P
pylori阳性组的血浆VIP含量显著低于H. pylori阴性组（P
7.Helicobacter pylori is one of the most prevalent human infections in the world and in most children infection with this organism is asymptomatic.
幽门螺杆菌(Helicobacter pylori，H.pylori)感染是世界范围广泛存在且最常见的细菌感染，小儿H. pylori感染绝大多数是无症状感染者。
8.Amis: To investigate the expression of tumor suppression gene and regulating gene of apoptosis in gastric mucosal lesions with Helicobacter pylori(H·pylori)infection.
目的:研究幽门螺杆菌(H·pylori)感染胃粘膜病变抑癌基因(p53、p16)和关键性凋亡调节基因bcl-2蛋白的表达,进一步探讨H·pylori在胃癌发生发展过程中作用的分子机制。
9.There was significantly different positivity rate of DGR between H.pylori-positive group and H.pylori-negative group (68.6% vs 40.0%,P
pylori阳性组十二指肠胃反流率 6 8.6 % (2 4 /35 )显著高于H . pylori阴性组十二指肠胃反流率 4 0 .0 % (12 /30 ) (P
10.Helicobacter pylon (H.pylori) has been attracted more attention sinceit was separated from gastric mucosa and cultured successfully by Marshalland Warren in 1982. 1-Lpyloni is a most important etiological factor ofchronic gastnitis and close association with peptic ulcer.
自从1982年Warren和Marshall从慢性活动性胃炎患者的胃粘膜中分离出幽门螺杆菌（Helicobacter pylori，H.pylori）以来，H. pylori受到了极大的关注。
