1.In the same ventilation modality, with the increase of PEEP level, PIP and mPaw of two vetilation modalities when PEEP =0.5, 1.0kPa was higher than that of PEEP=0 kPa (p
同一种通气模式下,随着PEEP水平的提高,两种通气模式的PIP和mPaw在PEEP=0.5、1.0和1.5kPa时均较PEEP=0kPa时高(p
2.Method The parameters of hemodynamics, lung mechanics, and gas exchange were compared at different levels of PEEP, including maximal static compliance PEEP, point inflection PEEP, 3 cmH 2O higher or lower than point inflection PEEP, and zero end expiratory pressure.
方法利用绵羊ARDS模型，比较0cmH2OPEEP，最大静态顺应性PEEP，吸气相静态P?V曲线低位曲折点消失的最小压力作为曲折点PEEP，和曲折点PEEP?3cmH2O（1cmH2O＝0?098kPa）与曲折点PEEP＋3cmH2O条件下，血流动力学、肺力学参数和肺气体交换的变化。
3.ResultsThere is a significant histological change (alveolar congestion, thickness of the alveolar wall, and leukocyte infiltration) in group B (VT=7 ml/kg, PEEP-16cm H2O) and C (VT=15 ml/kg, PEEP=0), whereas no significant alteration in group A (VT=7 ml/kg, PEEP=8cmH2O).
B组（VT－7 ml／kg；PEEP＝16 cmH20）和C组（VT－15 mUkg；PEEP＊）可见肺泡问隔明显充血增厚； 有大量中性粒细胞和淋巴细胞浸润。
4.Arterial blood gases and respiratory mechanics were recorded during IPPV.After oleic acid injection,15 dogs were randomly divided into 3 groups. These groups were treated with either IPPV alone (IPPV group)or IPPV with 0?981 kPa(1 kPa=10?20 cmH?2O) positive endexpiratory pressure (PEEP,PEEP group) or IPPV with -0?981 kPa CNEP (CNEP group).
注射油酸后（0．06ml／kg，静注）将15只犬随机分为3组：第1组为不加呼气末正压（PEEP）通气的IPPV（IPPV组），第2组为加0．981kPa（1kPa＝10．20cmH2O）PEEP的IPPV（PEEP组）； 第3组为加－0．981kPaCNEP的IPPV（CNEP组）。
5.Results FRC before and after alveolar recruitment manoeuvre with 5 cmH? 2 O PEEP were 48.5 13.5 ml and 103.5 21.2 ml respectively, that with 10 cmH? 2 O PEEP were 143 37.2 ml and 196 43 ml,15 cmH? 2 O PEEP were 166 34.2 ml and 241.5 42 ml.
(166±34.2)ml(前)/(241.5±42)ml(后); (2)使用RM后,压力-容量曲线低弯点,即病人所需最佳PEEP水平,呈逐步降低趋势;
6.Cst was kept in 33 6±8 3 ml/cmH 2O(PEEP 10～15 cmH 2O). The Cst and DO 2 were down gradually (PEEP>15cmH 2O). The peak inspiratory pressure (PIP) was increased ( P
结果 PaO2/FiO2随着PEEP的增高而增加,Cst在PEEP10～15cmH2O时,可稳定在336±83ml/cmH2O水平,当进一步增加时,Cst和DO2也进一步下降,PIP增加。
7.It suggested that: 1. When PEEP
结果表明,1.CPPV于PEEP
8.Result: Without using extrinsic PEEP, the peak airway pressure of IRV was lower than the IPPV′s, if there was a certain level of IRV was PEEP, both inverse ratio ventilation′s mean airway pressure would be higher than IPPV′s.
结果当PEEP=0 cmH2O时,两组IRV通气的气道峰压值低于IPPV通气时; 两组IRV通气的动物在各种PEEP水平时的平均气道压均显著高于IPPV组。
9.In Group C, the rate of suitability to PEEP was 60.0%, the average ideal PEEP was (3.2±2.5) cmH2O, and CV was 78.1%;
C组PEEP适应率为60.0%,理想PEEP平均值为(3.2±2.5)cmH2O,其变异系数为78.1%;
10.Conclusion:PEEP decreases CI and DO 2 by reducing preload of the heart and depressing cardiac systolic function when PEEP is more than 0.9 kPa(9 cmH 2O).
结论：当PEEP≥0．9kPa（9cmH2O）时，通过减少心脏前负荷，抑制心脏收缩功能，导致心脏指数和氧运送显著下降。
