1.DATA SOURCES:The Medline database was undertaken to identify the literatures of assessment of quality of life in patients with cancer published from February 1982 to January 2006 with the key words of "carcinoma,quality of life,laryngeal carcinoma" in English.
资料来源:应用计算机检索Medline 1982-02/2006-01关于癌症患者生活质量评估的文献,检索词“carcinoma,quality of life,laryngeal carcinoma”,限定语言种类为英文;
2.Objective To investigate the expression of the metastasis suppressor gene KAI1 in laryngeal squamous cell carcinoma and the relationship between expression of KAI1 and it′s role in tumorgenesis and development. Methods The sections of 84 samples of primary laryngeal squamous cell carcinoma (PLSCC), 27 samples of laryngeal precancerous lesion (LPL),10 samples of vocal cords polyp(VCP) and 10 samples of normal laryngeal tissues (NLT) were examined by in situ hybridization for KAI1mRNA.
目的 探讨肿瘤转移抑制基因KAI1在喉鳞状细胞癌 (简称鳞癌 )中的表达及其与之发生、发展的关系。 方法 采用原位杂交方法检测 84例原发性喉鳞癌 (primarylaryngealsquamouscellcarcinoma ,PLSCC)、2 7例喉癌前病变不典型增生 (laryngealprecancerouslesion ,LPL)、10例声带息肉(vocalcordpolyp ,VCP)和 10例正常喉黏膜 (normallaryngealtissues ,NLT)石蜡标本组织细胞中KAI1mRNA的表达。
3.Method:16 patients with hypopharyngeal and cervical esophageal carcinoma were treated with preserving laryngx in 8 cases, partial laryngectomy with laryngeal reconstruction in 3,voice reconstruction by blom-singer technique without laryngeal function preservation in 5.The types of hypopharyngeal and cervical esophageal reconstruction included gastrica transpostion, pectoralis major myocutaneous flap, free forearm flap, delto-pectoral skin flap, sternocleidomastoid myocutaneous flap, platysma smyocutaneous flap and laryngeal-tracheal flap following carcinoma resection.
方法 :对 16例下咽、颈段食管癌患者手术切除肿瘤后 ,实施保留全喉及部分喉切除喉功能重建 ; 全喉切除后行Blom Singer 1期、2期发声重建术 ,同时下咽及颈段食管缺损分别采用胃 咽吻合、前臂游离皮瓣、胸大肌肌皮瓣、胸三角皮瓣、胸锁乳突肌肌皮瓣、颈前肌皮瓣、喉气管粘膜瓣等方法进行整复。
4.The main trunks of ansa cervicalis were implanted into the laryngeal adductory muscles on the left side in seven dogs after the recurrent laryngeal nerve and the external branch of the superior laryngeal nerve were sectioned on the same side. After six months, a series of twitch, tetanic contractions were recorded from each side.
将7条犬的左喉返神经、喉上神经外支切断后,以左颈袢主支植入左声带内收肌中,6个月后用张力换能器检测。
5.Methods:29 dogs were divided into three groups. 24 dogs in the two experimental groups were reinnervated at 0,4,6,8,10 and 12 month interval following recurrent laryngeal nerve cut via the phrinic nerve anastomosed to the recurrent laryngeal nerve after cutting the adductor branch and ansa cervicalis sterothyroid muscle pedicle implanted into the posterior cricoarytenoid muscle. 5 dogs in the control group were not reinnervated after recurrent laryngeal nerve cut.
方法：将29只狗分成三组，两个实验组在喉返神经切断后即刻、4、6、8、10、12个月分别将膈神经与喉返神经吻合选择性支配环杓后肌和颈袢神经—胸骨甲状肌蒂植入环杓后肌，对照组喉返神经切断后各时间不作任何手术。
6.In immediate operation, 5 cases were repaired by direct recurrent laryngeal nerve suture, and 1 case was treated by transposition of the phrenic nerve to the recurrent laryngeal nerve and sutured the adductor branch to the branch of ansa cervicalis. In delayed operation, 3 cases were treated by anastomosis the main trunk of ansa cervicalis to the adductor branch of recurrent laryngeal nerve, and 3 cases were operated on neuromuscular pedicle to reinnervate posterior cricoarytenoid muscle.
喉返神经直接吻合5例，膈神经与喉返神经远侧断端吻合选择性支配环杓后肌，同时颈袢分支胸骨舌骨肌支与喉内收肌支吻合选择性支配喉内收肌1例，颈袢主支与喉返神经内收肌支吻合3例，颈袢胸骨甲状肌蒂植入左环杓后肌3例。
7.To investigate time of delayed reinnervated laryngeal muscle, 15 dogs were divided into two groups. The right recurrent laryngeal nerves of 10 dogs in experimental group were cut, and repaired at 4, 6, 8, 10 and 12 months intervals by transposition of the phrinic nerve to the recurrent laryngeal nerve after cutting and suturing the adductor branch to the main branch of ansa cervicalis.
为探讨延期喉内收及外展肌神经再支配术的时机，选用15只杂种犬为研究对象，在喉返神经切断后4，6，8，10及12个月，分别行膈神经与右喉返神经吻合，并切断内收肌支后，选择性支配右环杓后肌，颈袢主支与喉返神经的内收肌支吻合选择性支配喉内收肌。
8.Experimental study on the recurrent laryngeal nerve anastomosis for the treatment of laryngeal abductor paralysis
喉返神经吻合术治疗喉外展麻痹的实验研究
9.The adductor division of the recurrent laryngeal nerve was anastomosed with the main trunk of ansa cervicalis to reinnervate the vocal cord adductors after the one side of the recurrent laryngeal nerve section in seven dogs.
建立单侧喉麻痹模型，实验组作颈袢主支与喉返神经（RLN）内收肌支吻合术，对照组不作神经修复术。
10.OBJECTIVETo investigate the role of expression of the epithelial membrane protein 1 (EMP-1) and matrix mettallo-proteinases (MMP20, MMP3, MMP14 and MMP24) in laryngeal carcinogenesis and the relationship between their expression, the laryngeal biological behavior and the prognosis.
目的：探讨上皮膜蛋白基因-1(The epithelial membrane protein 1，EMP-1)、基质会属蛋白酶(Matrix Mettallo-proteinases，MMPs)在喉癌发生、侵润和转移中的作用及其表达与喉癌临床病理生物学行为和预后的关系。
