1.Some of them belonged to some important signal pathways related with cell proliferation and metastasis, such as DDK1, ILK, MMP-1 and COL11A1 in Wnt/β-catenin signal pathway, ILK in ILK signal pathway, EpHB2 in Eph-Ephrins signal pathway, ROCK2 in RhoA signal pathway, RANBP1 in RanGTPase signal pathway, and RBBP1 in RB/RBBP1 signal pathway.
其中包括一些非常重要的信号转导通路上的分子改变,如Wnt/β-catenin信号通路上的DKK1、ILK、MMP1、COL11A1,ILK信号通路上的ILK,Eph-Ephrins信号通路上的EpHB2,RhoA信号通路上的ROCK2,RanGTPase信号通路上的RANBP1,以及RB/RBBP1信号通路上的RBBP1等。
2.The proliferative index of ILK-high-expressed was the highest,and were higher than the others(P
细胞增殖率也以ILK基因转染细胞组最高,与其他二组比较有显著差异(Pa
3.Objective To observe the effect of small interference RNA(siRNA) of intergrin linked kinase(ILK) on the accumulation of fibronectin(FN) in the mesangial cells of aged rats,then to explore the role of ILK in the process of the age-related glomerular sclerosis.
目的观察整合素连接激酶(integrin linked k inase,ILK)小干扰RNA(small interference,siRNA)对衰老大鼠系膜细胞细胞外基质纤维连接蛋白(fibronectin,FN)的影响,探讨ILK在衰老肾脏肾小球硬化中的作用。
4.The level of ILK expression was negatively correlated with integrinα3 expression (r=-0.64, P＜0.05)and positively with urinary podocyte and albuminuria after 12 weeks (r=0.79 and 0.74, P＜0.05 respectively).
第12周,整合素α3蛋白表达与ILK表达呈负相关(P＜0．05)。 尿足细胞数量、尿白蛋白程度与ILK表达呈正相关(P＜0．05)。
5.OBJECTIVE:To investigate the difference of In te grin-linked kinase (ILK) mRNA expression in gastric carcinoma tissue and normal gastric tissue and analysis the relationship among the ILK mRNA expression and malignancy type,aggressive degree, nodal metastasis and clinical staging in gas tric carcinoma.
目的比较整合素连接激酶(in tegric linkedkimase,ILK)mRNA在胃癌组织及正常胃组织中表达的差异,分析ILKmRNA的表达与胃癌的病理类型、侵袭程度、淋巴转移、临床分期之间的关系。
6.ILK-siRNA inhibites the accumulation of fibronectin in mesangial cells of aged rats
ILK-siRNA抑制衰老大鼠系膜细胞纤维连接蛋白积聚的研究
7.Objective To explore the expression and significance of integrin-linked kinase(ILK) in the kidney of patients with IgA nephropathy.
目的探讨整合素连接激酶(ILK)在IgA肾病患者肾组织中的表达及其意义。
8.In comparison with the Group diabetes, the expression of ILK, α-SMA and Vimentin in renal tubular epithelial cells was apparently declined (P
氯沙坦组大鼠肾小管间质损伤指数、肾间质胶原面积较糖尿病组明显减弱,其肾小管上皮细胞的ILK,α-SMA与Vimentin表达均较糖尿病组明显减弱(P
9.The purpose of this study was to investigate the influence of Irb on the expression of recently recognized connective tissue growth factor (CTGF) and integrin-linked kinase (ILK) and its relationship with EMT in mice with unilateral ureteral obstruction (UUO). METHODS: UUO model was made as previously reported.
本研究通过单侧输尿管梗阻(UUO)模型观察AngⅡ1型受体拮抗剂厄贝沙坦(Irbesartan, Irb)对肾组织结缔组织生长因子(connective tissue growth factor, CTGF)和整合素连接激酶(integrin-linked kinase, ILK)表达的影响,并探讨其与肾小管上皮间充质转化的关系。
10.To investigate the roles of tyrosine kinase Src and related signaling molecules in regulating theadhesion and migration of vascular smooth muscle cells(VSMCs) ,the adhesion and migration of VSMCs wereinduced by osteoponin(OPN) ,and the effect of Src specific inhibitor PP2 on VSMC adhesion and migration as wellas focal adhesion kinase(FAK) and integrin-linked kinase(ILK) was studied.
为阐明酪氨酸激酶Src在整合素被骨桥蛋白(OPN)激活所触发的细胞黏附和迁移信号途径中所起的作用,应用Src特异性抑制剂PP2阻断Src,观察OPN诱导的血管平滑肌细胞(VSMC)黏附和迁移活性的改变,并利用免疫沉淀检查PP2对整合素下游信号分子黏着斑激酶(FAK)和整合素偶联激酶(ILK)磷酸化及其相互作用的影响。
