1.Methods Cultured HUVECs were randomly grouped as follows: control, Ang Ⅱ, Ang(1-7), Ang Ⅱ+Ang(1-7), HOE-140, and Ang Ⅱ+Ang(1-7)+HOE-140. Spectrophotometry and flow cytometry were used to evaluate lactate dehydrogenase (LDH) leakage and apoptosis percentage.
方法体外培养HUVECs,随机分为6组:对照组,AngⅡ组,Ang(1~7)组,AngⅡ+Ang(1~7)组,HOE-140组和AngⅡ+Ang(1~7)+HOE-140组。
2.The LVDP, LVEDP, arrythmia coronary flow and the enzymatic activity in myocardium were measured in group A, and TUNEL method was applied to probe apoptosis in group B. RESLUTS: It was found that the LVEDP, arrythmias and the enzymatic activity including CK-MB and LDH were significantly lower in group HOE-Pr+I/R than that in group I/R, while the LVDP was obviously higher in HOE-Pr+I/R than that in I/R.
B组分对照、I/R和HOE6 42 +I/R组 ,TUNEL法检测细胞凋亡。 结果 :HOE -Pr+I/R组在缺血复灌期间左室发展压明显高于I/R组 ,左室舒张末压、各时段心律失常评分低于I/R组 ,冠脉流出液心肌酶的含量也低于I/R组。
3.subjected to I R and received K/Mg (group 3) or K/Mg plus HOE 642 (group 4 through group 6);
④K/Mg I,HOE I; ⑤K/Mg I,HOE R ;
4.The concentration of CGRP in the perfusate was measured by RIA. The results showed that the CGRP release induced by ETX was inhibited by desamethasone, ibuprofen and indomethasin, all of which are inhibitors of PGs synthetase. HOE 140(BK 2 antagonist), WEB 2086(PAF antagonist), diphenhydramine(histamine H 1 antagonist) and cimetidine(histamine H 2 antagonist)also inhibited the CGRP release induced by ETX, but 5 HT 3 antagonist (ISC205 930) did not show significant effect.
结果显示：前列腺素合成酶抑制剂地塞米松、布洛芬与消炎痛，缓激肽受体B2拮抗剂HOE?140，血小板激活因子拮抗剂WEB2086，组胺H1受体拮抗剂苯海拉明以及和组胺H2受体拮抗剂西咪替丁，均能明显抑剂制内毒素引起的CGRP释放，5?羟色胺受体拮抗剂ICS205?930却无明显作用。
5.Results IS was markedly reduced in HOE 642 plus K/Mg treating groups, i.e., to( 4.6 ± 0.7 )%, ( 4.7±0.9 )%, (1.3±0.4)% in group 4, group 5 and group 6, respectively ( P
结果 所有HOE 6 42联合K/Mg组 (组④～组⑥ )心肌梗死量均明显减低 ,以组⑥最小 ,分别为 (4 .6± 0 .7) %、(4 .7± 0 .9) %、(1.3±0 .4) % (与组①、组②、组③比较 ,P
6.A new OE-HOE system has been worked out,with which the large-aperture collimated waves,large-aperture convergent wa- ves,astigmatic waves,or wave beam with cross-section of any aperture shape can be produced.
本文给出一种光学元件(OE)与全息光学元件(HOE)的组合系统,利用它可以获得大口径高精度准直波、大口径会聚球面波和象散波以及各种形状截面的光波。
7.Results Enalapril reduced the collagen content and Ⅰ/Ⅲ compared with the untreated MI group ( P
结果 依那普利、Losartan组的胶原含量及其Ⅰ /Ⅲ比值均较对照组降低(P
8.In groupⅢ,HOE642 was added to St. Thomas cardioplegia.
组Ⅲ在St．Thomas停跳液中加入HOE642;
9.CONCLUSION Pretreatment with HOE-642 can improve cardiac preservation markedly.
结论HOE-642预处理能明显改善心肌保护液对供体心肌的保护。
10.Moreover,HOE642 significantly reduced MDA and water content, increased ATP reserve (P
HOE642治疗组之间,组Ⅳ再灌注前15 min时+dp／dtmax、-dp／dtmax恢复率低于组Ⅱ和组Ⅲ(P
