1.To investigate the genetic susceptibility associated with cough related to ACE inhibitors therapy, Polymerase Chain Reaction (PCR) coupled with Single-Strand Conformation Polymorphism (SSCP) was used to detect polymorphism of ACE gene insertion/deletion (I/D) and bradykinin B2 receptor gene promoter -58T/C. Linkage analysis is carried out to evaluate the association of polymorphism of the two genes with cough induced by ACE inhibitors.
为了探讨ACEI所致咳嗽副反应的遗传易感性，应用多聚酶链式反应（Polymerase chain reaction，PCR）及单链构像多态性分析（Single-strand conformation polymorphism，SSCP）检测ACE基因插入/缺失（Insertion/deletion I/D）多态性与缓激肽B2受体基因启动子区-58T/C多态性，并连锁分析上述基因多态性与ACEI所致咳嗽的关系。
2.Some bands associated with trans or gauche conformation intensified or weakened with increased temperature, indicating that the conformation of propandiol segments (-O-CH2-CH2-CH2-O-) in the polymer chain changes after crystallization—the inner two C-C-C bonds conversed from trans to gauche, while the outer two C-O bonds conversed from gauche to trans conformation.
发现随着温度上升,显示结晶的谱带略有增强,PTT分子链中丙二醇单元(-O-CH2-CH2-CH2-O-)的构象发生了转变:中间的两个碳碳键(C-C-C)由反式构象向旁式构象转变,同时两边的两个碳氧键(C-O)由旁式构象转变为反式构象。
3.The CD spectra of L-aspa-raginase and PEG2-L-asparaginase under different conditions proved that Asn and Gln have serious effect on the conformation of native enzyme but very slight effect on the conformation of modified enzyme.
天冬酰胺酶和PEG_2-天冬酰胺酶的CD光谱表明:天冬酰胺和谷氨酰胺对天冬酰胺酶和PEG_2-天冬酰胺酶的构象影响较大,但天冬酰胺酶和PEG_2-天冬酰胺酶的构象变化趋势有明显的不同。
4.AFM-based single molecule force spectroscopy and optical tweezers can be used to study the molecule-level mechanical problems of polymer materials, which include the strength and elastic properties of single polymer chain, force-induced conformation transition of polymer chain, interaction among polymer molecules, adsorption strength and conformation of polymer chain on solid substrates, nanometer-scale viscoelasticity measurement and nano-tribology of polymer surfaces.
摘要基于原子力显微技术的单分子力谱法和光钳法可用于研究聚合物材料分子层次上存在的力学问题，包括聚合物分子链的强度、弹性性质及外力作用下的构象转变、分子间相互作用、聚合物分子的界面吸附以及聚合物表面的纳米粘弹性和纳米摩擦学等问题。
5.Methods Micrococcal nuclease (MCN) and deoxyribonuclease I ( DNase I) were used as the probe to differentiate chromatin conformation and agarose gel electrophoresis and polyacrylamide gel electrophoresis (PAGE) were employed to investigate the changes of chromatin conformation in rats with different ages.
方法 选用微球菌核酸酶 (MCN)和脱氧核糖核酸酶I(DNaseI)作为染色质结构识别探针 ,经琼脂糖和聚丙烯酰胺凝胶电泳 (PAGE) ,显示老年大鼠和青年大鼠下丘脑、垂体神经细胞核染色质的结构变化。
6.The Tm and Ti of compounds 18 is higher than the compounds 16.The Tm and Tj of compounds 18 II and 16 II which have the trans conformation is higher than those of compounds 18 I and 16 I having cis conformation.
化合物 16和 18中，反式构型的化合物 16II和 ISll的熔点和液晶态的清亮点均高于顺式构型的化合物 161和 ISI。
7.Methods According to the earlier literature, the fragment of mitochondrial DNA from nucl eotide 3153 to 3551, which had shown high frequency of point mutation, was scann ed with the technique of polymerase chain reaction-single strand conformation p olymorphism (PCR-SSCP) in Chinese normal control, type 2 diabetic population, a nd 12 families suffering from maternally inherited type 2 diabetes mellitus. Dir ect sequencing was applied to detect the fragments with abnormal conformation.
方法 针对已经报道的线粒体基因的高发突变区(mt315 3～ 35 5 1)近 40 0bp的片段在中国人正常人群、2型糖尿病群体及 12个母系遗传的 2型糖尿病家系中进行聚合酶链反应 单链构象多态性 (polymerasechainreaction singlestrandconformationpolymorphism ,PCR SSCP)研究 ,发现异常构象再进行DNA序列测定。
8.In this paper, B3LYP/6-311G(d,p) method was applied to study the conformation stabilities of dipeptide molecule CH_3CONHCH_3. Conformation analysis was carried out from the point of view of intramolecule hydrogen bond interaction, steric interaction, and Coulomb interactions.
使用B3LYP/6 311G(d,p)方法对二肽分子CH3CO[NHCH2CO]NHCH3的所有可能稳定构象进行了研究,分析了二肽分子CH3CO[NHCH2CO]NHCH3的不同稳定构象的相对稳定性,从分子内氢键作用、大基团间的空间位阻以及库仑作用角度探讨了影响二肽构象稳定性的因素.
9.IEC culture line was used as a model to investigate the effect of Copper-loaded Silicate Nanoparticles (CSN) on the conformation, proliferation, differentation and migration of chick IEC.
然后以IEC细胞系为实验模型,研究载铜硅酸盐纳米微粒(CSN)对鸡IEC形态、增殖、分化及损伤后细胞迁移的影响。
10.It is well known that German Angora not only for its higher wool yield and wool quility but also for earlier mature and larger body conformation.
德系安哥拉兔不仅以产毛量高、毛质好而著称,而且有生长迅速、体成熟早、体型大的特点。
