1.Objective To study the plasma level and its clinical significance of complement C3 (C3), complement C4 (C4) and high sensitive C-reactive protein (Hs-CRP) in patients with cerehral infarction in acute period.
目的观察脑梗死急性期血清补体C3(Complement C3)、补体C4(Complement C4)、高敏C-反应蛋白(Hs-CRP)改变,并探讨其临床意义。
2.Being cascade reaction, complement activation is strictly controlled by many regulators of complement activation. Among these regulators, membrane cofactor protein ( MCP),decay acceleration factor (DAF), membrane inhibitor of reactive lysis ( CD59,MIRL) are more effective.
补体激活做为一种级联反应受到多种补体调节因子(Regulators of Complement Activation，RCA)的严格控制，这些调节因子中以膜辅助蛋白(MCP)、衰变加速因子(DAF)和膜反应性溶解抑制物(CD59、MIRL)的作用尤为显著。
3.The researcher overseas have reported the single nucleotide polymorphisms (SNPs) of the complement factor H (CFH) gene were strongly associated with AMD recently. A positive association between Y402H polymorphism of the complement factor H (CFH) gene and AMD has been recently reported in North American and European populations.
近年来,国外研究者发现补体因子H基因(complement factor H gene,CFH/HF1 )的单核苷酸多态性( single nucleotide polymorphisms ; SNPs)与AMD相关,在北美和欧洲人口中均发现CFH基因中的Y402H的变化与AMD的发生相关联,这种基因多态性大约占AMD发病危险的50%左右。
4.The efficiency of CDC against tumor mostly depends on the activation of complement proteins, which are regulated by complement regulatory proteins (CRP).
由于补体调节蛋白(complement regulatory proteins,CRP)调控补体活化的各个步骤,探讨其在肿瘤组织的表达和临床意义已成为补体杀伤肿瘤研究的热点。 CD55、CD59作为主要抑制补体活化的CRP,能调节CDC作用的强弱。
5.Antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) are involved in the mechanisms underlying the efficiency of MAb against tumor.
单克隆抗体作用肿瘤细胞相应的分子靶点后,产生的生物学效应主要包括抗体依赖性细胞毒作用(antibody dependent cellular cytotoxicity,ADCC)和补体依赖性细胞毒作用(complement-dependent cytotoxicity,CDC)。
6.The clinical application of murine monoclonal antibodies is associated with a number of drawbacks, including inducement of human anti-mouse antibody (HAMA), short circulating time in vivo, and the inability to fully harness the effectors (ADCC) and complement (CDC) repertoire of the human immune system. Genetic engineering has been used to humanize mouse mAb and can overcome the drawbacks significantly.
鼠源单克隆抗体在临床应用中有以下缺点:诱发人体产生人抗小鼠抗体(human anti-mounse antibody,HAMA)反应,在人体内半寿期短,不能够有效地激活人体的生物效应功能,如补体依赖的细胞毒作用(complement-dependent cytotoxicity,CDC)及抗体依赖性细胞介导的细胞毒作用(antibody-dependent cell-mediated cytotoxicity,ADCC)。
7.In line with the NegP Hypothesis, Cheng & Li (1991) and Chiu (1993) argue that the Neg morphemes Bu and Mei in Chinese are heads, projecting a structure and selecting either a VP or AuxP complement.
Cheng & Li(1991)及Chiu(1993)采用否定短语假说,认为否定词素“不”是一个功能中心词(functional head),映射否定短语(NegP),并选择系动词短语(AuxP)或动词短语(VP)为其补语(complement)。
8.There were no statistical differences among three groups for age, sex, cold ischemia time/heat ischemia time of donor kidney, complement dependent cyctoxicity (CDC) and level of panel reactive antibody (PRA).
3组患者在性别、年龄、供肾冷热缺血时间、淋巴细胞毒试验(complement dependent cytotoxicity,CDC)、群体反应抗体(panel reactive antibody，PRA)水平等方面无显著差异。
9.Abstract: The article deals with the language units in different language meanings in the expression in Chinese language,and analyses the ways of expressing and rhetorical functions,as well as mentions the five ways of understanding the language units in different language meanings,one-way repellency,one-way complement,two-way mutual complement, one-way repellency and complement, two-way repellency and complement.
文摘:洋学院教务处，浙江舟山316004）[摘要]汉语表达中的言意差异意域，具有丰富的表现形式及修辞作用，理解言意差异意域的方法有单向排斥、单向补充、双向互补、单向排斥补充、双向排斥补充。
10.Objective: To study the relationship between the complement system and the pathogenesis of allergic rhinitis, through investigate the protein level and the level of mRNA expression of Complement C_3,C_4 and Complement Regulatory Proteins C_1-INH、 MCP (CD46) in the nasal mucosa of allergic rhinitis rat.Methods: 20 healthy SD rats were randomly allotted into AR group and control group, 10 rats for each group.
目的:研究补体C_3、C_4及补体调节蛋白C_1-INH、MCP(CD46)在大鼠变应性鼻炎中mRNA表达和翻译的变化,证实补体及补体调节蛋白在变应性鼻炎发病中的作用,以期进一步揭示变应性鼻炎的发病机制。
