1.CML is caused by a reciprocal chromosome translocation between chromosome 9 and 22, resulting in the short Philadelphia (Ph) chromosome carrying the BCR-ABL (Breakpoint Cluster Region-Abelson Leukaemia) oncogene.
CML的分子遗传学特征是费城染色体(Philadelphia chromosome，Ph)的出现。
2.Objective To study the bcr/abl fusion gene in chronic myeloid leukemia (CML) cases with Philadelphia chromosome(Ph)negative,and variant Ph translocations and other chromosome anomalies.
目的 检测费城染色体 (Philadelphia chromosome,Ph染色体 )阴性、变异型 Ph染色体及伴有其它染色体异常的慢性粒细胞白血病 (chronic myeloid leukemia,CML)的 bcr/abl融合基因。
3.Method: salmonella typhimurium mutagenicity test (Ames test), chromosome aberration (CA) test of cultivated cells of mammalian, micronucleus test in mice and mammalian bone marrow CA test were used.
方法：应用鼠伤寒沙门菌回复突变实验（Ames实验）、哺乳动物培养细胞染色体畸变（Chromosome Aberration, CA）实验、小鼠微核（Micronucleus, MN）实验和哺乳动物骨髓细胞CA实验。
4.The effect of oleic acid on phosphotase and tensin homology deleted on chromosome ten (PTEN) mRNA expression inβTC3 cells was investigated. Oleic acid increased PTEN mRNA expression and activated ATP-sensitive potassium channel. It suggests that it may exist an important mechanism of impairing islet function by high lipid.
研究油酸慢性作用对BβTC3细胞PTEN(phosphotase and tensin homology deleted on chromosome ten)mRNA表达的影响,结果显示油酸增加PTEN的表达,使ATP敏感性K+通道开放,这可能是高脂损害胰岛功能的机制之一。
5.ALEX2 (Arm proteins lost in epithelial cancers, X chromosome. 2) is the member of the ALEX family of proteins which includes ALEX1, ALEX2, and ALEX3. Members of the ALEX family of proteins were found to co-localized at the same region in Xq21.33-q22.2 and they all cotain arm repeat domains. Li the N-terminal parts of the proteins they all have putative transmembrane domain.
ALEX2基因(Arm proteins lost in epithelial cancers,X chromosome,2),属于ALEX家族成员,除ALEX2基因外,该家族还包括ALEX1和ALEX3基因。
6.Modification of bacterial artificial chromosome (BAC) has been a useful method for studying gene expression and function in vitro and in vivo.
对细菌人工染色体(bacterial artificial chromosome,BAC)的修饰是研究基因在体内和体外表达和功能的一个有用的方法。
7.The aiploid chromosome number is 60,x chromosome is a large submetacentric and Y chromosome is a small qcrocentric,but Y chromosome of hybria bull is a small submeta-centris,Besides chromosome 2.3.4.11 and 28,the Ag—NORs are also situated on chromosome 21.The Ag—NOR frequency on chromosome 21 and 28 are respectively 0.11 and 1.79 per cell.
温岭牛的Ag—NORs除定位于2、3、4、11、28号染色体上之外,在21号染色体上也有银染颗粒,但出现频率很低。 21号和28号染色体末端Ag—NOR出现频率分别为每细胞0.11个和1.79个。
8.The karyotype and chromosome number of Acacia holosericea,were analysed on meristematic cell of root tips The result showed that the chromosome number in each somatic cell was 2 n=4 x=52(tetraploid) According to the classification made by L C Saylor,the Karyotype formula is K(2 n)=4 x=52=44 m+4 sm+4 st According to the chromosome length<2 μm,the chromosome of Acacia holosericea belongs to a small chromosome
研究绢毛相思的染色体数目及核型．绢毛相思体细胞染色体数目是2n＝4x＝52，为四倍体．其核型组成为K（2n）＝52＝44m＋4sm＋4st； 染色体长度均在2μm以下，为小染色体
9.The X chromosome was a metacentric chromosome whose length was between the 8 th and 9 th chromosome, while the Y chromosome was a smallest metacentric chromosome.
X染色体为中着丝点染色体，大小介于第8对和第9对染色体之间，Y染色体为最小的中着丝点染色体。
10.it was found that the diploid of the breed was 2n=60, the karyotype of bulls was 60, xy, of cows was 60, xx, X Chromosome was a large submetacentric Chromosome, y Chromosome was a small Submetacentric Chromosome, its arm ratio was 1. 722. The Karyotype and C-banded in Red Danish were the same as in Bos taurus.
结果表明，丹麦红牛二倍体为2n＝60，公平核型为60，xy，母牛为60，xx，x染色体为一大的亚中着丝粒染色体，y染色体为一小的亚中着丝粒染色体，其臂比为1．722。
