1.Methods In the past 8 years, 32 patients aged 75 or over underwent coronary artery bypass grafting(CABG). 25 cases underwent off-pump coronary artery bypass grafting (OPCAB),4 cases had CABG with cardiopulmonary bypass(CPB), and 3 cases had combined mitral valve replacement and CABG.
方法对近8年来32例75岁以上冠心病病人行冠状动脉旁路移植术(coronary artery bypass grafting,CABG),其中行不停搏冠状动脉旁路移植术25例,体外循环下冠状动脉旁路移植术4例(占12%),体外循环下冠状动脉旁路移植术加二尖瓣置换3例(占9%)。
2.Methods Clinical records of patients undergoing coronary artery bypass surgery at this department between June 2002 to December 2005 were reviewed. There were 113 patients(OPCAB Group) with a higher(>5) EuroSCORE(European system for cardiac operative risk evaluation) risk of death. Another group of 76 high-risk patients(EuroSCORE > 5) receiving cardiopulmonary coronary artery bypass grafting(CCAB) during the same period was reviewed as control group(CCAB Group).
方法回顾分析2002年6月~2005年12月OPCAB术的临床资料,根据欧洲心脏手术风险评分模型(European system for cardiac operative risk evaluation,EuroSCORE)计算每一病例的风险分数,>5分者作为高风险病例进入本研究,共113例,以同期行体外循环冠状动脉旁路移植(cardiopulmonary bypass coronary artery bypass grafting,CCAB)的76例高风险患者作为对照。
3.Recently, systemic inflammatory response syndrome (SIRS) induced by cardiopulmonary bypass(CPB)had been considered as an important mechanism in which acute renal injury associated with CPB devoloped.
目前,人们多认为体外循环(cardiopulmonary bypass;CPB)引起的全身性炎症反应综合征(systemic inflammatory response syndrome;SIRS)是导致CPB相关急性肾损伤的重要因素。
4.Background: Acute lung injury (ALI) is one of the main complications and one of the main causes of death after cardiopulmonary bypass (CPB) in infants.
背景:婴幼儿体外循环(cardiopulmonary bypass,CPB)术后肺损伤、呼吸功能不全已成为其主要的并发症与死亡原因之一,婴幼儿CPB术后引起急性肺损伤(acute lung injury,ALI)的发生机制,至今尚未明确阐述。
5.Objective To investigate theories of liver injury,protective effects of ulinastatin (UTI) on liver and give the clinical proof for the use of ulinastatin in cardiopulmonary bypass during open heart surgery.
目的 探讨乌司他丁(ulinastatin UTI)在体外循环(Cardiopulmonary bypass,CPB)心脏手术期间对肝脏的保护作用,为乌司他丁在体外循环心脏手术中的应用提供临床依据。
6.Leukocytes activation had been proven to be the central role in tbe initiationand development of cardiopulmonary bypass(CPB) induced systemic inflammatory response, it also had intimate relationship to the CPB induced systemic inflammatory response syndrome and multipule organ dysfunction or even failure, especially respiratory failure.
白细胞激活是心肺转流术(cardiopulmonary bypass，CPB)心脏直视手术致全身性炎症反应发生和发展中的重要环节，它和CPB诱发的全身性炎症反应综合征(systemic inflammatory response syndrome，SIRS)及术后多器官功能不全综合征和多器官衰竭，尤其是呼吸功能衰竭的发生有密切关系。
7.Objective: To investigate the effect of Shenfu injection (SFI) on myocardium ischemia-reperfusion injury (IRI) in mitral valve replacement (MVR) with cardiopulmonary bypass (CPB) and its action mechanism and proper medication.
目的：观察参附注射液（Shenfu injection, SFI）对体外循环（cardiopulmonary bypass, CPB）二尖瓣置换术（mitral valve replacement, MVR）心肌缺血-再灌注损伤（ischemia-reperfusion injury, IRI）的影响及其合适用药方法。
8.Objective:To investigate the effects of ulinastatin (UTI) on liver in cardiopulmonary bypass during open heart surgery.
目的:探讨乌司他丁(ulinastatin,UTI)在体外循环(cardiopulmonary bypass,CPB)心脏手术期间对肝脏的作用,为乌司他丁在体外循环心脏手术中的应用提供临床依据。
9.In CAD patients with 2-and 3-vessels or long and diffuse pathology and CAV patients are not candidators for conventional therapies as PTCA(Percutaneous transluminal coronary angioplasty),CABG. (Coronary artery bypass grafting) and medicine .
CAD中冠状动脉弥漫性狭窄、闭塞者与CAV相似，目前常规治疗方法如PTCA(Percutaneous transluminal coronary angioplasty，经皮腔内冠状血管成形)、CABG(Coronary artery bypass grafting，冠状动脉旁路移植)和药物等都不适宜，迫切需要找到、开展疗效好、创伤小的治疗方法。
10.BackgroundSystemic inflammatory response syndrome (SIRS) induced by cardio- pulmonary bypass (CPB) is an irritant reaction when the bodies are injured by CPB. The excess inflammatory response will induce tissue injury or organ dysfunctions, even severe complications such as inflammation, sepsis , acute respiratory distress syndrome and multiple organs dysfunction syndrome (MODS) will happen.
体外循环(cardiopulmonary bypass，CPB)诱发的全身炎症反应综合症(systemic inflammatory response syndrome，SIRS)是机体对CPB创伤的一种应激反应，过度或失控的炎症反应可以引起组织损伤和器官功能紊乱，引发感染、败血症、急性呼吸窘迫症及多器官功能不全(multiple organs dysfunction syndrome，MODS)等严重并发症。
