1.HCY inhibited significantly L arginine transport of ECs in a concentration dependent manner. The L arginine transport in 0.01 mmol·L -1 HCY group was decreased. Incubation of ECs with 0.1 and 1.0 mmol·L -1 HCY not only markedly lowered V max for L arginine transport, but also obviously elevated the value of K m, so L arginine transport efficiency was potently decreased.
HCY呈浓度依赖地降低内皮细胞L arginine转运 ,0 .0 1mmol·L- 1 HCY即明显抑制细胞L arginine转运速率 ,0 .1、1mmol·L- 1 HCY不仅显著降低细胞L arginine最大转运速率 ,而且增高米氏常数 ,降低了转运效率。
2.Conclusion: The data show that HCY induces dysfunction of L arginine/NOS/NO pathway in vascular ECs,and potently inhibits L arginine transport, suggesting that the effect of HCY inhibited cellular L arginine transport could be one of the pathogenetic mechanisms, by which HCY induces cardiovascular impairement.
结论 :HCY损伤人血管内皮细胞L arginine NO途径 ,尤其是抑制细胞L arginine转运 ,这可能是HCY导致心血管疾病时心血管功能和结构损伤的重要机制之一。
3.Objective:We studied the effects of L arginine (L arg,nitric oxide precursor) and N G nitric L arginine m ethyl ester (L NAME,nitric oxide synthase inhibitor) on intracellular free calcium concentration of myocardial cell ([Ca 2+ ] i) under hypoxic condition.
目的 :探讨左旋精氨酸 (L - arginine,L - arg)及 NG-亚硝基 - L -精氨酸甲酯 (NG- nitric- L - arginine- methyl ester,L NAME)对缺氧豚鼠心肌细胞内游离钙浓度 ([Ca2 + ]i)变化影响。
4.Methods Thirty five dogs were randomly divided into 5 groups (7 in each), namely groups of stunned, reperfusion of NG nitro L arginine methyl ester (L NAME), L Arginine(L Arg), 3 morpholino sydnonimine (Sin 1) and control.
方法 将 35条犬随机分为 5组 (每组 7条 ) ,即MS组、亚硝基左旋精氨酸甲酯 (NG nitro L argininemethylester,L NAME)组、左旋精氨酸 (L Arginine,L Arg)组、3 morpholinosydnonimine (Sin 1,一种NO供体 )再灌注组及对照组。
5.Objective: To explore the impact of L arginine ( L Arg ) on apoptosis of smooth muscle cells in pulmonary arteries of the rats with hypoxic pulmonary vascular structural remodeling.
目的 :探讨L 精氨酸 (L arginine ,L Arg)对低氧性肺血管结构重建大鼠肺动脉平滑肌细胞凋亡的影响及其机制。
6.Effects of L-arginine on apoptosis of brain cells and MVD after focal cerebral ischemia
L-arginine对局灶脑缺血脑细胞凋亡和微血管密度的影响
7.in order to further comfirm the effect of NO, the inhibitors of iNOS, Dexamethasone(DXS) and N w -nitro-L-arginine (L-NNA), were used to inhibit the production of NO, larvicidal activity was measured by the same methods and the difference of dead larvae ratio was compared between the inhibited and uninhibited groups.
同时，为进一步证实NO对六钩蚴的杀伤作用，分别用诱导型一氧化氮合酶(iNOS)的抑制剂地塞米松(Dexamethasone，DEX)和左旋硝基精氨酸(Nω -nitro-L-arginine，L-NNA)抑制NO产生，与未加抑制剂组比较，观察六钩蚴死亡率的变化。
8.Objective: To study the role of nitric oxide (NO) in hippocampal delayed neuronal death (DND) after transient global ischemia and observe the effects of nonselective nitric oxide synthase (NOS) inhibitor N G nitro L arginine(L NNA)on DND.
目的 :研究一氧化氮 ( NO)在缺血性海马迟发性神经元死亡 ( DND)中的作用 ,观察非选择性一氧化氮合酶 ( nitricoxidesynthase,NOS)抑制剂 NG-nitro-L-arginine( L-NNA)对缺血性海马 DND的影响。
9.AIM To investigate the changes of L arginine (L Arg)transportation kinetic characteristics in erythrocytes (RBC) and platelets (pt) of patients with essential hypertension (EH).
目的 探讨原发性高血压 (EH)时人体血液系统 L -精氨酸 (L - Arginine,L - Arg)载体转运功能的改变 .
10.ObjectiveTo study the effect of arginine vasopressin (AW) and oxytocin (OT) on neurons of dorsal root ganglion (DRG) and its mechanisms in the rat.Method
研究精氨酸加压素(Arginine vasopressin，AVP)和催产素(Oxytocin,OT)对大鼠背根神经节(DRG)神经元的作用并探讨其作用机制。
