1.It was found that preincubation of CHIP and CDDP with guanosine could partially abrogate the inhibitory effect of these platinum compounds on 3H-TdR incorporation into Ehrilch ascites carcinoma (EAC) cells.
实验发现,外源性的鸟嘌呤核苷预先与CHIP或CDDP作用后,可以部分地扭转两药对~3H—TdR掺入小鼠艾氏腹水癌(EAC)细胞的抑制作用,而鸟嘌呤核苷本身对~3H—TdR的掺入并无影响; 外源性的腺嘌呤核苷不能改变CHIP或CDDP的作用;
2.Our results obtained from experiments on syngeneic mice show that (1) expression of allogenic MHC class II, B7 or IL-2 can abrogate the tumorigenicity of immunogenic EL4 tumor cells; and reduce the tumorigenicity and metastatic potential of non-immunogenic B16 tumor cells.
首先，建立了一套表达小鼠H-2A~d、mB7和IL-2的逆转录病毒载体系统，通过逆转录病毒介导使H-2A~d、mB7和IL-2单独或联合在免疫原性的小鼠T淋巴瘤EL4(MHCⅠ~+)和非免疫原性黑色素瘤B16(MHCⅠ~-)细胞中表达，动物实验的结果表明：
3.The results showed that TNF-α upregulated expression of nuclear protein p65 and downregulated expressions of OPG mRNA and protein, pyrrolidine dithiocarbamate did not abrogate the downregulation of OPG expression induced by TNF-α in MG-63 cells.
结果显示:TNF -α上调MG 63细胞核蛋白p65表达,下调护骨素(OPG)mRNA和蛋白质表达。 吡咯二硫氨基甲酸酯不能阻止TNF -α下调MG 63细胞OPG的作用。
4.There was a greater tendency to be reflected that the rates of P53 expression increase in HCC with advanced Edmondson stages. In HCC with P53 positively expression, the ratio of apoptosis declined markedly with the increase expression of PCNA-LI, it showed that the overexpression of P53 contribute to the proliferation of HCC and abrogate the its apoptosis.
提示P53过度表达与HCC细胞分化和浸润转移可能相关，P53阳性HCC，细胞凋亡指数显著降低，而PCNA一LI显著增高，提示P53蛋白过度表达对HCC的细胞增殖可能有促进作用，对其细胞凋亡有一定的抑制作用。
5.Conclusion Wild type p53 genes promote G 1 phase arrest and apoptosis of tumor cells following irradiation,while those with mutant or vect p53 genes abrogate this response to irradiation.
结论 野生型p53 基因具有促进照射后肿瘤细胞的G1 期阻滞和凋亡作用，而p53 变异和缺失则减低了肿瘤细胞对放射线的反应。
6.Results Pretreatment with glutamine could abrogate the high levels of plasma ALT activity,the density of TNF-α and MDA in liver by Galn/LPS,and maintain the density of GSH.
结果谷氨酰胺预处理可抑制Galn/LPS导致的血浆ALT活性、肝组织TNFα、MDA水平的升高,维持GSH的浓度。
7.To annul; abrogate.
废除，取消
8.In consideration of the comparison between the costs of the control of the capital account and the benefits of the abrogation of the said control, China shall abrogate the control of capital account without hesitation.
从资本项目管制的成本和取消资本项目管制的效益的对比来看,我国应该完全取消资本项目管制。
9.Methods:Whole cell extracts from human NK cell lines(YT,IL 2 independent;NK 92,IL 2 dependent) was used in Western blot to detect the constitutively activated signal transduction pathway(s) in human NK cell lines. Specific inhibitor PD098059 was used to abrogate phosphorylation of ERK1/2 for further evaluation.
方法 :制备NK 92和YT细胞的全细胞提取物 ,进行Westernblot,检测在细胞系中持续活化的信号传导途径 ,信号通路特异性阻断剂PD0 980 5 9阻断ERK1 2活化 ,MTT方法评价ERK1 2在调节NK细胞杀伤和增殖活性中发挥的作用 ,RT PCR检测阻断试剂作用前后杀伤相关分子表达水平的变化。
10.Pretreating with CAPE,a potent and specific inhibitor of activation of NF-κB ,could abrogate IL-1β induced RANTES expression in RF. Conclusion: RANTES may be associated with the pathogenesis of GO. NF-κB is partially involved in the IL-1β-mediated action on RANTES in RF.
结论:IL1β诱导RF表达的RANTES参与了GO眶后淋巴细胞浸润,且RANTES的表达可能与NF-κB的激活有关。
